Cancer metastasis

Prevention of cancer metastasis is a central challenge in cancer therapy. Therefore, it is of great interest to gain a better understanding of the interactions involved in this process. The extracellular matrix in the tumor environment is known to be a key player in cancer cell invasion.

In this video, Annalena Laurent, based on the work of Lang et al. and Ahmadzadeh et al., illustrates how changes in the mechanical properties of the extracellular matrix can affect the invasiveness of breast cancer cells.

Annalena Laurent is a student in the Cell Physics Master at the University of Strasbourg, France.

Find the original scientific publications described in this video below.

● Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks

● Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion